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显微镜成像软件和可选的显微镜阐发软件

MetaMorph® 显微镜主动化及成像阐发软件可节制图象主动收罗、硬件装备节制和成像阐发。它可将差别的荧鲜明微镜硬件和核心装备轻松整合到一台客户定制的任务站中。该软件供给很多简略易用的利用模块,用于生物特征阐发。两个软件补充包,用于荧光比率成像的 MetaFluor® 软件和用于根本图象收罗和处置的 MetaVue® 软件均包罗在此组合中。

  • 撑持第三方显微镜

    撑持第三方显微镜

    MetaMorph 软件与很多市道上可买到的显微镜、激光发射、TIRF 光学组件兼容,并且可在之前已装置且与 MetaMorph 软件兼容的成像体系上利用。

  • 测定荧光比率成像

    测定荧光比率成像

    MetaFluor® 荧光比率成像软件用于测订单或多波长细胞内离子旌旗灯号来为离子互换和细胞内功效供给更深切的领会。

  • 记实和阐发图象

    记实和阐发图象

    MetaVue™ 科研成像体系是一个简略易用的软件利用法式,用于收罗和处置图象、履行图象操纵、存档和检索图象。

接纳基于定位的超高分辩率显微镜可处置份子构造和能源学

接纳定位型超分辩率显微成像来阐发份子构成和能源学

特色

  • 及时图象处置

    经由历程图形处置硬件加快来撑持图象处置。可分辩小到空间 20nm和轴向40nm的亚细胞东西。

  • 多维收罗模块

    可以或许利用矫捷的带领式用户界面来获得庞杂的图象收罗序列。

  • 综合外形丈量阐发

    按照外形、巨细或光密度等外形丈量参数的肆意组合来测定东西,并将其分类到用户可自界说的邃密种别中。

  • 扫描玻片模块

    主动收罗多个图象,随后将其无缝拼接在一路。很是合用于大型构造样品,可在确保反复性的同时防止拼接尝试中的预测臆断。

  • 装备和摄像机持续拍摄

    可加快图象捕获速度并在收罗时代将图象同步传输到存储器,从而赞助活细胞/静态成像等利用来捕获静态细胞事务。

  • 撑持 3D 测定的 4D 检查器

    用于多维可视化的东西包含: 时候序列图象、多个 Z 层切、波长、时候点和地位。可停止数据衬着并用于检查3D 等值面和扭转。

  • 产物手册

    彩页

    Molecular Devices 的 MetaMorph® 显微镜主动化和图象阐发软件在这场变更中起到很大感化。凭仗其图象收罗、处置和阐发功效...

MetaMorph 显微镜主动化及成像阐发软件的资本

报告内容
视频和收集钻研会
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接纳基于定位的超高分辩率显微镜可处置份子构造和能源学

接纳定位型超分辩率显微成像来阐发份子构成和能源学

及时单份子基超高分辩率显微镜重修:实际和实际洞察力

基于及时单份子的超分辩率显微重修:实际和实际洞察

  • Number of Citations*: 25,000

    Latest Citations: For a complete list, please .

    *Source:

  • Citation
    Dated: Aug 20, 2011
    Publication Name: Journal of Nanoparticle Research

    Catalytic nanoparticles represent a potential clinical approach to replace or correct aberrant enzymatic activities in patients. Several diseases, including many blinding eye diseases, are promoted by excessive oxidant stress due to reactive oxygen species (ROS). Cerium oxide and platinum nanoparticles represent two potentially therapeutic… View more

    Catalytic nanoparticles represent a potential clinical approach to replace or correct aberrant enzymatic activities in patients. Several diseases, including many blinding eye diseases, are promoted by excessive oxidant stress due to reactive oxygen species (ROS). Cerium oxide and platinum nanoparticles represent two potentially therapeutic nanoparticles that de-toxify ROS. In the present study, we directly compare these two classes of catalytic nanoparticles. Cerium oxide and platinum nanoparticles were found to be 16 ± 2.4 and 1.9 ± 0.2 nm in diameter, respectively. Using surface plasmon-enhanced microscopy, we find that these nanoparticles associate with cells. Furthermore, cerium oxide and platinum nanoparticles demonstrated superoxide dismutase catalytic activity, but did not promote hemolytic or cytolytic pathways in living cells. Importantly, both cerium oxide and platinum nanoparticles reduce oxidant-mediated apoptosis in target cells as judged by the activation of caspase 3. The ability to diminish apoptosis may contribute to maintaining healthy tissues.

    Contributors: Andrea Clark, Aiping Zhu, Kai Sun & Howard R. Petty  

  • Citation
    Dated: Aug 30, 2007
    Publication Name: Journal of Neuroscience Methods

    Automated image-based and biochemical assays have greatly increased throughput for quantifying cell numbers in in vitro studies. However, it has been more difficult to automate the counting of specific cell types with complex morphologies in mixed cell cultures. We have developed a fully automated, fast, accurate and objective method for the… View more

    Automated image-based and biochemical assays have greatly increased throughput for quantifying cell numbers in in vitro studies. However, it has been more difficult to automate the counting of specific cell types with complex morphologies in mixed cell cultures. We have developed a fully automated, fast, accurate and objective method for the quantification of primary human GFAP-positive astrocytes and CD45-positive microglia from images of mixed cell populations. This method, called the complex cell count (CCC) assay, utilizes a combination of image processing and analysis operations from MetaMorph™ (Version 6.2.6, Molecular Devices). The CCC assay consists of four main aspects: image processing with a unique combination of morphology filters; digital thresholding; integrated morphometry analysis; and a configuration of object standards. The time needed to analyze each image is 1.82 s. Significant correlations have been consistently achieved between the data obtained from CCC analysis and manual cell counts. This assay can quickly and accurately quantify the number of human astrocytes and microglia in mixed cell culture and can be applied to quantifying a range of other cells/objects with complex morphology in neuroscience research.

    Contributors: Pritika J.Narayan, Hannah M.Gibbons, Edward W.Mee, Richard L.Faull, Michae Dragunow  

  • Citation
    Dated: Mar 21, 2007
    Publication Name: Journal of Neuroscience

    How a naive human neuroepithelial cell becomes an electrophysiologically active neuron remains unknown. Here, we describe the early physiological development of neurons differentiating from naive human embryonic stem (hES) cells. We found that differentiating neuronal cells progressively decrease their resting membrane potential, gain… View more

    How a naive human neuroepithelial cell becomes an electrophysiologically active neuron remains unknown. Here, we describe the early physiological development of neurons differentiating from naive human embryonic stem (hES) cells. We found that differentiating neuronal cells progressively decrease their resting membrane potential, gain characteristic Na+ and K+ currents, and fire mature action potentials by 7 weeks of differentiation.

    Contributors: M. Austin Johnson, Jason P. Weick, Robert A. Pearce and Su-Chun Zhang  

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